Dr. Abraham Koshy

Director of Hepatology & Research, VPS Lakeshore
Dr. Abraham Koshy has extensive experience of more than 45 years in Gastroenterology and Hepatology. He completed his medical graduation from CMC, Vellore and post-graduation in Gastroenterology from AIIMS, New Delhi. He acquired FAASLD (Fellow of the American Association for the Study of Liver Diseases). He worked as professor of Gastroenterology over 16 years. He is skilled in the management of patients with complex liver diseases and transplant recipients. He has expertise in Cirrhosis and Hepatitis. He has over 99 publications in peer-reviewed medical journals.
Hospital
  • VPS Lakeshore Hospital, Maradu, Kochi, Kerala, India

Experience
  • Teaching faculty at Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
  • Teaching faculty at Sanjay Gandhi Post-Graduate Institute, Lucknow
  • Teaching faculty at St. Jones Medical College, Bangalore
  • Research experience at the University of Paris (INSERM)
  • Research experience at the University of Bern, (Switzerland)
  • Research experience at Academic Medical Centre (Amsterdam, Netherlands)
  • Observed medical liver transplant management at Royal Free Hospital, London
  • Observed medical liver transplant management at University of Miami, U.S.A
  • Observed medical liver transplant management at King’s College, London
  • Observed medical liver transplant management at Virginia Commonwealth University, Richmond, VA, U.S.A

Education
  • MBBS from CMC, Vellore
  • MD (General Medicine)
  • DM (Gastroenterology) from AIIMS (All India Institute of Medical Sciences)in 1976

Fellowship and Training
  • Fellow of the American Association for the Study of Liver Diseases (FAASLD)

Papers Published
  • 'Causes, Clinical Features, Outcomes and Predictors of Mortality from a Nationwide Prospective Study of Drug‐Induced Liver Injury' - Hepatology, October 2019
  • 'Causes, Clinical Features, and Outcome of Patients with Drug‐Induced Acute Liver Failure from a Nationwide Prospective Study of Drug‐Induced Liver Injury' - Hepatology, October 2019
  • 'Hemochromatosis in India: First Report of Whole Exome Sequencing With Review of the Literature' - Journalof Clinical and Experimental Hepatology, April 2019
  • 'Sofosbuvir–velpatasvir single-tablet regimen administered for 12 weeks in a phase 3 study with minimal monitoring in India' - Hepatology International, February 2019
  • 'Findings from a large Asian chronic hepatitis C real-life study' - Journal of Viral Hepatitis, August 2018
  • '10. NAFLD score as an indicator to perform MR elastography in non alcoholic fatty liver disease' - Journal of Clinical and Edxperimental Hepatology, July 2018
  • 'Endoscopic ultrasound-guided coil or glue injection in post-cyanoacrylate gastric variceal re-bleed' - Indian Journal of Gastroenterology, April 2018
  • 'Unexpected findings from a large Asian HCV real life study' - Journal of Hepatology, April 2018
  • 'Multi-center prospective survey of inflammatory bowel diseases in Kerala: More than 2000 cases' - Indian Journal of Gastroenterology, January 2018
  • 'Predictors of Mortality in Treated Severe Alcoholic Hepatitis at Six Months' - Journal of Clinical and Experimental Hepatology, July 2017
  • '1112 Eus Guided Coiling for Rectal Varices' - Gastrointestinal Endoscopy, May 2017
  • 'Sofosbuvir plus ribavirin in treatment-naïve patients with chronic hepatitis C virus genotype 1 or 3 infection in India' - Journal of Viral Hepatitis, December 2016
  • 'Corrigendum to “Indian National Association for Study of the Liver (INASL) guidance for antiviral therapy against HCV infection: Update 2016” [J. Clin. Exp. Hepatol. 6 (2016) 119–145]' - Journal of Clinical and Experimental Hepatology, September 2016
  • 'Indian National Association for Study of the Liver (INASL) Guidance for Antiviral Therapy Against HCV Infection: Update 2016' - Journal of Clinical and Experimental Hepatology, July 2016
  • 'Correlation of BMI with Subcutaneous Fat and Total Body Fat in Patients with NAFLD in South India' - Journal of Clinical and Experimental Hepatology, July 2016
  • 'Relationship of Severity of Hepatitis A With Genetic Polymorphisms in Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene' - Journal of Clinical and Experimental Hepatology, July 2016
  • 'Normal Values for Psychometric Tests, for Kerala; and Its Evaluation in Cirrhotic Patients' - Journal of Clinical and Experimental Hepatology, July 2016
  • 'Su1986 EUS Guided Coiling in Post Cyanoacrylate Gastric Variceal Rebleed' - Gastrointestinal Endoscopy, May 2016
  • 'Bronchobiliary Fistula Treated Successfully With Endoscopic Microcoils and Glue' - The Annals of Thoracic Surgery, August 2014
  • 'Pegylated interferon alfa-2b plus ribavirin for treatment of chronic hepatitis C' - World Journal of Hepatology, July 2014
  • 'Consensus statement of HCV Task Force of the Indian National Association for Study of the Liver (INASL). Part I: status report on HCV infection in India' - Journal of Clinical and Experimental Hepatology, June 2014
  • 'Consensus statement of HCV task force of the Indian National Association for Study of the Liver (INASL). Part II: INASL recommendations for management of HCV in India' - Journal of Clinical and Experimental Hepatology, June 2014
  • 'Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: Report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study' - Indian Journal of Gastroenterology, September 2013
  • 'Entecavir + tenofovir combination improved survivial in acute severe hepatitis B' - Journal of Clinical and Experimental Hepatology, March 2013
  • 'Stellate Cell Activation in Tropical Calcific Pancreatitis Compared to Alcoholic Pancreatitis, Adenocarcinoma of Pancreas and Normal Pancreas' - Journal of the Pancreas, July 2012
  • 'Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force' - Indian Journal of Gastroenterology, May 2011
  • 'Minimal hepatic encephalopathy: Consensus statement of a working party of the Indian National Association for Study of the Liver' - Journal of Gastroenterology and Hepatology, June 2010
  • 'Progressive familial intrahepatic cholestasis: A case with improvement in liver tests and growth following partial external biliary diversion' - Indian Journal of Gastroenterology, May 2009
  • 'The Tunisian population history through the Crigler-Najjar type I syndrome' - European Journal of Human Genetics, July 2008
  • 'Endoscopic removal of chicken bone that caused gastric perforation and liver abscess' - Indian Journal of Gastroenterology, September 2007
  • 'High FVIII Level Is Associated with Idiopathic Portal Vein Thrombosis in South India' - The American Journal of Medicine, July 2007
  • 'Non-healing gastric ulcer associated with Candida infection' - Indian Journal of Medical Microbiology, February 2007
  • 'Glycogen storage disease: Report of 17 cases from southern India' - Indian Journal of Gastroenterology, July 2006
  • 'Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in Southern India' - Indian Journal of Gastroenterology, May 2006
  • 'Medical treatment of portal biliopathy' - Journal of Clinical Gastroenterology, May 2006
  • 'Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis' - Annals of Hematology, March 2006
  • 'Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice' - Comparative Hepatology, February 2006
  • 'Endothelial nitric oxide synthase is not essential for the development of fibrosis and portal hypertension in bile duct ligated mice' - Liver International, November 2005
  • 'Familial High Factor VIII Level Associated With Hepatic Vein Thrombosis' - Journal of Clinical Gastroenterology, October 2004
  • 'Nitric Oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis' - Liver International, September 2004
  • 'Crigler-Najjar Syndrome Type 1 Associated With Combined 1070A→G, Q357R and (TA)7 Mutation in Kuwaiti Bedouin Families Indicate a Founder Effect in Arabs' - Journal of Clinical Gastroenterology, May 2004
  • 'Treatment of hepatitis C virus genotype 4-related cirrhosis - Ribavirin and interferon combination compared with interferon alone' - Journal of Clinical Gastroenterology, July 2002
  • 'Leishmaniasis Diagnosed by Liver Biopsy' - Journal of Clinical Gastroenterology, April 2001
  • 'Adrenomedullin replaces no to maintain hyperdynamic circulation in cirrhotic NOS3 knockout mice' - Journal of Hepatology, April 2001
  • 'Sensitivity to endothelin 1 (ET1) is decreased in ecNO synthase knockout mice associated with downregulation of ET A receptors' - Journal of Hepatology, December 2000
  • 'Improved response to ribavirin interferon combination compared with interferon alone in patients with type 4 chronic hepatitis C without cirrhosis' - Liver International, August 2000
  • 'Crohn's disease presenting as pyogenic liver abscess with review of previous case reports' - The American Journal of Gastroenterology, January 1999
  • 'Systemic and Portal Hemodynamic Response to Propranolol in Patients with Portal Hypertension Due to Hepatitis C Virus' - Medical Principles and Practice, July1998
  • 'Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C' - Hepatology, September 1997
  • 'Experience with More than One Hundred Trans Jugular Liver Biopsies in Kuwait' - Annals of Saudi Medicine, August 1996
  • 'Short-term IgM and IgG Antibody Responses to Hepatitis E Virus Infection'- Infectious Diseases, February 1996
  • 'High prevalence of anti-HCV among Egyptian blood donors is associated with anti-schistosomal antibody' - Hepatology, January 1996
  • 'Urinary Schistosomiasis Associated With Hepatitis C Virus Infection' - The Journal of Urology, April 1995
  • 'Acute sporadic hepatitis E in Kuwait' - Journal of Medical Virology, April 1994
  • 'Rapid Decline in Antibodies to Hepatitis-E Virus May Explain Frequency of Acute Hepatitis-E Infection in Adults from Endemic Countries' - Hepatology, April 1994
  • 'Egyptians with Anti-HCV Positive Chronic Active Hepatitis Respond Poorly to Interferon' - Hepatology, April 1994
  • 'Anti-HCV-positive cirrhosis associated with schistosomiasis' - The American Journal of Gastroenterology, October 1993
  • 'Is Dialysis Environment More Important Than Blood Transfusion in Transmission of Hepatitis C Virus during Hemodialysis?' - Vox Sanguinins, February 1993
  • 'Effects of α 1 and β-adrenergic antagonists and 5-hydroxytryptamine receptor antagonist on portal-systemic collateral vascular resistance in conscious rats with portal hypertension' - Journal of Gastroenterology and Hepatology, October 1992 & September 1992
  • 'Hepatitis C Virus Antibody in Kuwait' - Vox Sanguinis, February & January 1992
  • 'Scoring system for portal hypertension' - Indian Journal of Gastroenterology, November 1991
  • 'Effects of haemorrhage and Volume expansion on portal-systemic collateral vascular resistance in conscious portal hypertensive rats' - Clinical Science, March 1990
  • 'Heterogeneous Hepatic Venous Pressures in Patients with Liver Cancer' - Journal of Clinical Gastroenterology, March 1990
  • 'Effects of oxygen inhalation on tissue oxygenation in patients with cirrhosis. Evidence for an impaired arterial baroreflex control' - Journal of Hepatology, October 1989
  • 'Reduction of portal pressure by acute administration of furosemide in patients with alcoholic cirrhosis' - Journal of Hepatology, October 1989
  • 'Somatostatin Analogue Improves Survival in Conscious Cirrhotic Rats Subjected to Gastrointestinal Bleeding' - Clinical Science, August 1989
  • 'Effects of glucagon on systemic splanchnic circulation in conscious rats with biliary cirrhosis' - Journal of Hepatology, August 1989
  • 'Beta blockers in portal hypertension--current status' - Tropical Gastroenterology, July 1989
  • 'Discrepancy between systemic and splanchnic hemodynamic changes after incremental doses of propranolol in awake portal hypertensive rats' - Hepatology, February 1989
  • 'Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: Search for an additive effect' - Hepatology, January 1989
  • 'Model for the study of portal-systemic collateral vascular resistance in the conscious rat' - Journal of Pharmacological Methods, December 1988
  • 'Glucagon selectively increases splanchnic blood flow in patients with well-compensated cirrhosis' - Hepatology, November 1988
  • 'Effect of the development of portosystemic shunts in the maintenance of portal hypertension in rats' - Gastroenterologie Clinique et Biologioue, August 1988
  • 'Systemic and splanchnic hemodynamic effects of intravenous hypertonic glucose in patients with cirrhosis' - Hepatology, May 1988
  • 'Retrograde filling of the right main hepatic vein on percutaneous splenoportography' - Indian Journal of Gastroenterology, May 1988
  • 'Regional Blood Flows by the Microsphere Method: Reproducibility in Portal Hypertensive Rats and Influence of a Portal Vein Catheter' - Proceedings of The Society for Experimental Biology and Medicine- May 1988
  • 'Circulatory effects of somatostatin analogue in two conscious rat models of portal hypertension' - Gastroenterology, April 1988
  • 'Effects of different vasoactive substances on portal-systemic collateral vascular resistance in conscious portal hypertensive rats' - Hepatology, January 1988
  • 'Possible deleterious hemodynamic effect of nifedipine on portal hypertension in patients with cirrhosis' - Clinical Pharmacology & Therapeutics, October 1987
  • 'Leprosy, liver and jaundice' - Indian Journal of Leprosy, April 1987
  • 'Blood counts in portal hypertension of non-cirrhotic origin: correlation with splenic size and splenic pulp pressure' - Indian Journal of Gastroenterology, February 1986
  • 'Heparin and lieno-renal shunt patency' - Indian Journal of Gastroenterology, August 1985
  • 'Liver span in normal Indians' - Indian Journal of Gastroenterology, May 1985
  • 'Injection sclerotherapy for bleeding varices--a review' - Indian Journal of Gastroenterology, February 1985
  • 'Clinical differentiation between portal vein thrombosis (PVT), non-cirrhotic portal fibrosis (NCPF) and cirrhosis by discriminant analysis' - Indian Journal of Gastroenterology, November 1984
  • 'Clinical and investigative discrimination between portal vein thrombosis, non-cirrhotic portal fibrosis and cirrhosis' - Indian Journal of Gastroenterology, November 1984
  • 'Follow-up of survivors of epidemic veno-occlusive disease in India' - The Lancet, April 1984
  • 'Follow-up of survivors of epidemic veno-occlusive disease in India' - The Lancet, April 1984
  • 'Bleeding in extrahepatic portal vein obstruction' - Indian Journal of Gastroenterology, February 1984

Focus Areas
  • Gastroenterology
  • Hepatology

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